Cosmetic composition, cosmetic treatment method, kit, and compound

ABSTRACT

The invention relates to a cosmetic composition, especially a hair composition, and to a method for the cosmetic treatment of keratin materials, especially of the hair, employing compounds of formula: 
                         
in which Z represents (i) a hydrogen atom, (ii) a linear or branched C1 to C32 (saturated) alkyl radical; (iii) a linear or branched C2 to C32 (unsaturated) alkene radical, comprising one or two C═C double bonds; (iv) an aryl-substituted alkyl radical; said radicals being optionally substituted and/or interrupted.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a National Phase filing under 35 U.S.C. § 371 ofPCT/FR2011/050005 filed on Jan. 4, 2011; and this application claimspriority to Application No. 1050003 filed in France on Jan. 4, 2010, andthis application claims the benefit of U.S. Provisional Application No.61/292,255 filed on Jan. 5, 2010, under 35 U.S.C. § 119; the entirecontents of all are hereby incorporated by reference.

The present invention relates to a method for the cosmetic treatment ofkeratin materials, especially of the hair, using a compositioncomprising compounds capable of forming hydrogen bonds, and also to thecosmetic compositions thus prepared, and to a kit comprising thiscomposition.

In the cosmetics industry, there is a constant desire to improve theproperties of keratin materials and to combat damage, such as externalattacks, for instance pollution and ultraviolet radiation, or chemicalattacks, for instance those caused by oxidizing, reducing or alkalinedyeing or permanent-waving treatments. Among the damage suffered by thehair, mention may especially be made of the increased hydrophilicnature, the loss or the detachment of some of the scales, anddifficulties in disentangling.

In order to improve the properties of the hair, it is known practice touse compositions containing cosmetic active agents in order to providethe keratin materials, such as the hair, with all the beneficial effectsassociated with these cosmetic active agents. However, the persistenceand therefore the effectiveness of these active agents are notsufficient, since they can be easily removed with shampoo, or else theydo not form a homogeneous deposit at the surface of the hair.

The objective of the present invention is to propose a cosmeticcomposition capable of being used for the cosmetic treatment of thehair, and of giving the hair long-lasting cosmetic properties.

Indeed, it has been observed that compounds comprising entities capableof forming physical interactions with one another can give the hairadvantageous cosmetic qualities. These compounds are especiallycharacterized by the presence of at least one entity capable of givingat least 3 hydrogen bonds, in particular 4 hydrogen bonds, and also bytheir low mass.

One subject of the present invention is therefore a cosmetic compositioncomprising, in a cosmetically acceptable medium, at least one compoundof formula (I) as defined below.

Another subject of the invention is a method for the cosmetic treatmentof keratin materials, consisting in applying such a cosmetic compositionto said keratin materials.

Another subject of the invention is a kit comprising said composition.

Particular compounds, of formula (Ia), constitute yet another subject ofthe invention.

It has been observed that depositing a compound according to theinvention onto the skin or the hair or causing a compound according tothe invention to penetrate into the hair makes it possible to providethe hair with a beneficial effect. Without being bound by the presentexplanation, it is possible to imagine that ureidopyrimidone entitiesare capable of generating, in situ in or on the hair, a crosslinkednetwork by physical associations between molecules. When deposited onthe hair or the skin, said compound becomes involved in and trapped in acrosslinked deposit, which increases its persistence, in particular withrespect to sebum, water and shampoo.

Furthermore, since the crosslinking is a physical crosslinking, it ispossible for the effect to be persistent while at the same time allowingthe compound to be removed during makeup removal. The removal of thedeposit may consist especially of rinsing with a cleansing compositionapplied at room temperature or at a temperature above 25° C., or throughthe use of a makeup remover, or by using any known hydrogen bondbreaker.

Many compounds that incorporate ureido-pyrimidone (UPY) units have beendescribed in the literature and studied for their self-assembly propertyby fundamental research laboratories. However, none of these documentsdescribes the application of these compounds to keratin materials, noreven their possible use for strengthening said materials.

In the cosmetic field, mention may be made of WO 02/098377 whichdescribes, in a general manner, compounds with UPY units for cosmeticapplications to the skin and the hair. Mention may also be made of WO2003/032929 which describes the preparation of supramolecular polymersand the use thereof in hair applications. Mention may also be made of WO2004/016598 which describes the preparation of supramolecular polymersand the use thereof in various applications, including cosmeticapplications. Alternatively, mention may be made of WO 2005/042641 whichdescribes the preparation of supramolecular polymers, especially ofpolyurethane type, and the use thereof in various applications,including cosmetic applications.

In all of these documents, the compounds described are polymers,therefore compounds of high molecular weight, which will not thereforepenetrate into the hair in order to provide it with beneficialproperties, in particular in terms of protection of the hair.

The present invention may also make it possible to hydrate andstrengthen or even repair keratin materials, and to provide long-lastingsoftness to them, such that the effect remains perceptible after atleast one shampoo wash. The expression “strengthening of keratinmaterials” is understood to mean in particular an improvement in themechanical properties which may result in:

-   -   an increase in their rigidity, which gives them greater strength        and body; or else    -   a decrease in their deformation, in particular under wet        conditions, which allows the hair to readily return to its        initial shape once dried, and results in an improvement in the        dynamics of the hair; or else    -   a better resistance to tensile mechanical forces which are        applied thereto, for example during combing, and which can lead        to breaking of the hair;    -   a decrease in its porosity or in its swelling in water. Indeed,        it is known that hair damaged by oxidizing, reducing or alkaline        treatments is more porous than undamaged hair, which results in        a faster diffusion of water further into the core and has the        effect of increasing the diameter of the hair in a wet        environment (The Science of Hair Care, p. 416, 2^(nd) edition,        ed. C. Bouillon, J. Wilkinson, 2005).

Furthermore, it is possible to generate a network, in situ, in the hair,which will make it possible to provide the hair with protection orrepair properties, following a dyeing, bleaching, permanent-waving,smoothing or straightening treatment for example. Creating thiscrosslinked network in the hair also makes it possible to avoidpremature bleeding of a dye.

The compounds according to the invention may therefore both coat thehair, and therefore provide in particular strengthening properties, andalso penetrate into the hair and provide, in situ, protection or repairproperties in particular.

Moreover, it has been observed that the use of compounds according tothe invention on hair straightened by an alkaline treatment makes itpossible to transform the hair in a manner that is resistant to shampoowashes, in other words to increase the straightening performanceswithout increasing the porosity of said hair; this effect stillremaining perceptible after 5 shampoo washes.

It has also been observed that the application of certain compoundsaccording to the invention to damaged, and therefore hydrophilic hairhas the effect of repairing the surface of said hair by rendering itlastingly hydrophobic, and of facilitating the disentangling thereof ina wet environment.

Furthermore, it has been observed that the association of certaincompounds according to the invention, applied in the form of 3successive low concentration (0.1% AM) applications to damaged hair,previously reduced with a 0.2M thioglycolic acid treatment has theeffect of re-establishing the modulus of rigidity of the hair.

The compounds according to the invention may therefore be appliedbefore, during or after a cosmetic hair dyeing, bleaching,permanent-waving, straightening or smoothing treatment, or else as amaintenance treatment for hair damaged by external attacks such as UV,pollution, repeated brushing and chlorinated water.

The compound capable of being employed within the context of theinvention therefore corresponds to the formula (I), salts thereof,addition salts thereof, isomers thereof, solvates thereof, especiallyhydrates thereof, the tautomeric forms being included:

in which:

-   -   R1 and R2, independently of one another, represent H, —OH, —NRR′        (with R, R′, which may be identical or different, being H or a        linear or branched C1-C12, preferably C1-C4 alkyl radical, and        better still a methyl or ethyl radical); or a linear, branched        and/or cyclic, saturated or unsaturated, optionally aromatic,        C1-C18, preferably C1-C12 carbon-based group, especially an        alkyl group, which may contain one or more O, N and/or S        heteroatoms, especially OH, COOH and/or NRR′.

The radicals R1 and R2 may especially be chosen from:

-   -   H;    -   NH₂;    -   a C1-C18 alkyl group, optionally substituted with one or more        NH₂, COOH and/or OH functions;    -   a C4-C12 cycloalkyl group, optionally substituted with one or        more NH₂, COOH and/or OH functions;    -   a C4-C12 aryl group, optionally substituted with one or more        NH₂, COOH and/or OH functions; and/or optionally substituted        with one or more PEG groups of formula —(CH₂CH₂O)_(m)— with m=2        to 15;    -   a C1-C4 alkoxy group;    -   an aryl(C1-C4)alkoxy group; optionally substituted with one or        more NH₂, COOH and/or OH functions.

Preferably, R1 represents H.

Preferably, R2 represents H, CH₃, C₇H₁₅, C₁₃H₂₇ or aryl.

Preferentially, R1=H and R2=methyl.

-   -   Z represents a monovalent radical chosen from:        (i) a hydrogen atom,        (ii) a linear or branched C1 to C32, especially C2-C24 or even        C3-C18, better still C4-C12 (saturated) alkyl radical;        (iii) a linear or branched C2 to C32, especially C2-C24 or even        C3-C18 (unsaturated) alkene radical, comprising one or two C═C        double bonds;        (iv) a C1-C32, especially C2-C24, or even C3-C18, better still        C4-C12 alkyl radical, substituted with a C6-C10, especially        C6-C8 aryl; in particular phenyl;        it being possible for said radicals to optionally be substituted        with 1 to 8, especially 2 to 6 or even 3 to 5 groups chosen from        —OH, —OR, —SH, —SR, —SO₃H, —SO₃R, —SO₂NRR′, —COOH, —COOR,        —CONRR′, —NR—C(O)—NRR′, —NRR′ and —N⁺RR′R″, with R, R′ and R″=H        or C1-C6 alkyl, especially methyl; and the substituents of        formula (a) to (h) below:

and/or it being possible for said radicals to optionally comprise 1 to8, especially 2 to 6 or even 3 to 5 divalent groups chosen from, aloneor as a mixture, —S—, S(O), SO₂, —NH— (or ═NH), —O—, —C(O)—, —C(═NH)—,—N⁺(CH₃)₂-An⁻ (An⁻: anion); or else —N═ (trivalent).

For the sake of clarity, it is specified that the Z radical cannotcomprise the group:

Preferably, the Z radical comprises 0 to 12 heteroatoms, especially 1 to10, or even 2 to 6 heteroatoms.

Preferably, the Z radical, when it is substituted, is substituted by 1to 8, especially 2 to 6, or even 3 to 5 groups chosen from —OH, —SH,—SO₃H, —COOH, —NRR′ and —N⁺RR′R″, with R, R′ and R″=H or C1-C6 alkyl,especially methyl; and the substituents of formula (a) to (h).

Preferably, the Z radical, when it is interrupted, is interrupted by 1to 8, especially 2 to 6, or even 3 to 5 divalent groups chosen from,alone or as a mixture, —S—, —NH— (or ═NH), —O—, —C(O)—, —C(═NH)—,—N⁺(CH₃)₂—.

Among the compounds of formula (I) that are particularly preferred,mention may be made of the following compounds:

Preferably, the weight-average molecular weight (M_(w)) of the compoundof formula (I) according to the invention is less than or equal to 1200g/mol. This low molecular weight favours in particular the penetrationof the compounds into the hair.

The present invention also relates to certain novel compounds, offormula (Ia), and also the tautomeric forms thereof and the saltsthereof:

in which Z represents a monovalent radical chosen from:(i) a non-cyclic, saturated or unsaturated, linear or branched, C1 toC32 hydrocarbon-based radical,

-   -   optionally substituted with 1 to 20 hydroxyl radicals —OH,        and/or    -   optionally interrupted by 1 to 10 identical or different groups        chosen from, alone or combined with one another, —S—, S(O), SO₂,        —NH— (or ═NH), —N═ (trivalent), —O—, —C(O)—, —CH(OH)—, —C(═NH)—,        —N⁺(CH₃)₂—, C6-C10, especially C6-C8, aryl (cyclic aromatic)        radical. Preferably, the interrupting group is chosen from the        groups —NH—, —C(O)—, —CH(OH)—, —N⁺(CH₃)₂— or is nonexistent;        preferably the non-cyclic hydrocarbon-based radical is a linear        C3 to C10 radical;    -   terminated with a group chosen from —NR₁R₂, —N⁺R₁R₂R₃An⁻,        —NHC(O)OR₄, —CH(NH₂)CO₂R₄, —NHC(O)CH(OH)(CH₂)₂OH, in which:        R₁, R₂, R₃, independently represent a linear or branched C1-C6        alkyl radical, especially a methyl or ethyl radical, or a        hydroxyalkyl radical, especially a hydroxyethyl radical; or an        aminoalkyl radical, especially a —(CH₂)₄—NH₂ radical;        R₄ represents a hydrogen atom H or a linear or branched C1-C6        alkyl radical, especially a methyl, ethyl or tert-butyl radical,        or a hydroxyalkyl radical, especially a hydroxyethyl radical;        An⁻ denotes a cosmetically acceptable anion or a mixture of        cosmetically acceptable anions;        (ii) a radical of formula (A1):        —(CH₂)_(p)—(X)_(n)—(CH₂)_(q)—NR₆—C(═NH)—NR₇R₈        in which X denotes a group chosen from —S—, S(O), SO₂, —NH— (or        ═NH), —N═ (trivalent), —O—, —C(O)—, —C(═NH)—, —C(O)O—, —OC(O)—,        —NC(O)—, —NC(O)N—, NSO₂N—, —NR₆—C(═NH)—NR₇—, —N⁺(CH₃)₂— An⁻, a        C6-C10, especially C6-C8, aryl (cyclic aromatic) radical.        Preferably, the interrupting group is equal to —NH—C(O)—NH—;        An⁻ denotes a cosmetically acceptable anion or a mixture of        cosmetically acceptable anions.        n, p and q are integers and        n=0 to 8;        p=1 to 10;        q=1 to 10;        p+q≠5.

Preferably, n=0 or 1, p+q is between 4 and 10, p+q≠5.

More preferably, n=0 and p+q=4.

R₆, R₇, R₈ independently denote a hydrogen atom H, a linear or branchedC1-C6 alkyl radical, especially a methyl or ethyl radical, or ahydroxyalkyl radical, especially a hydroxyethyl radical.

Preferably, R₆, R₇, R₈ independently denote a hydrogen atom H or amethyl or ethyl radical.

More preferably, R₆, R₇, R₈ are identical and represent a hydrogen atomH.

(iii) a radical of formula (A2):—(CH₂)_(r)-(T)_(s)-(CH₂)_(t)—(CHR₉)_(u)—(CH₂)_(v)—SiR₁₀R₁₁R₁₂ in which Tdenotes a group chosen from the groups: —S—, S(O), SO₂, —NH— (or ═NH),—N═ (trivalent), —O—, —C(O)—, —C(═NH)—, —N⁺(CH₃)₂— An⁻, a C6-C10,especially C6-C8, aryl (cyclic aromatic) radical, a carbon-carbon doublebond, especially —CH═CH—, a carbon-carbon triple bond, and combinationsthereof.

Preferably, T represents a group —NH—C(O)—NH— or —NH—C(O)—O—.

When s, respectively u, is not zero, the adjacent T groups, respectivelyadjacent —CHR₉— groups, are identical or different.

R₉ denotes a radical chosen from the radicals: —OH, —SH, —SO₃H, —COOH,—COOR, —NHC(O)R, NHC(O)OR, —NRR′ and —N⁺RR′R″ An⁻, in which R, R′ andR″, which may be identical or different, represent a hydrogen atom H ora linear or branched C1-C6 alkyl radical, especially a methyl radical;

R₁₀, R₁₁, R₁₂ are chosen independently from OR₁₃ radicals or linear orbranched C1-C6 alkyl radicals;

R₁₃ denotes a linear or branched C1-C6 alkyl radical, or a radical—(CH₂—CH₂—O)_(w)R₁₄ or a radical —SiR₁₆R₁₆R₁₇.

R₁₄ denotes a hydrogen atom H, or a methyl radical.

R₁₅, R₁₆ and R₁₇ independently denote a linear or branched C1-C4 alkylradical.

Preferably R₁₃ represents a methyl or ethyl radical or an SiMe₃ radical.

An⁻ denotes a cosmetically acceptable anion or a mixture of cosmeticallyacceptable anions.

r, s, t, u, v, w are integers and

r=1 to 10;

s, t, u, v=0 to 10;

w=1 to 5;

it being understood that when s=u=0 and R₁₀=R₁₁=R₁₂=OR₁₃, then r+t+v≠3.

Preferably, s=0 or 1, u=0, r+t+v is between 1 and 10, more preferablybetween 3 and 9.

(iv) a radical of formula (A3): —(CH₂)_(x)—(U)_(y)—(CH₂)_(z)—CH₃

in which U denotes a group chosen from the radicals: —S—, S(O), SO₂,—NH— (or ═NH), —N═ (trivalent), —O—, —C(O)—, —C(═NH)—, —N⁺(CH₃)₂-An⁻, aC6-C10, especially C6-C8, aryl (cyclic aromatic) radical, acarbon-carbon double bond, especially —CH═CH—, a carbon-carbon triplebond, and also combinations thereof;An⁻ denotes a cosmetically acceptable anion or a mixture of cosmeticallyacceptable anions.x, y and z are integers, between 0 and 10 inclusive;it being understood that when y=0, x+z is greater than or equal to 10and less than or equal to 30 and other than 18, in particular x+z isequal to 15;and that when y≠0, x is greater than or equal to 2 and less than orequal to 25 and z is greater than or equal to 3 and less than or equalto 25, in particular x+z is equal to 15 with U equal to C═C and y=1;(v) a radical of formula (A4): -Alk1-(V)_(a1)-(Alk2)_(a2)-CH₂—Win which Alk1 and Alk2 independently denote a saturated or unsaturated,linear or branched, C1 to C32 alkyl radical. Preferably the alkylradical is a saturated C1 to C10 alkyl radical.V denotes a group chosen from the radicals: —S—, S(O), SO₂, —NH— (or═NH), —N═ (trivalent), —O—, —C(O)—, —C(═NH)—, —N⁺(CH₃)₂-An⁻, a C6-C10,especially C6-C8, aryl (cyclic aromatic) radical, a carbon-carbon doublebond, especially —CH═CH—, a carbon-carbon triple bond, or combinationsthereof. Preferably, V represents a group chosen from: —NH—C(O)—,NH—C(O)—NH—, —NH—CO—O—, O—C(O)—, —N⁺(CH₃)₂-An⁻.An⁻ denotes a cosmetically acceptable anion or a mixture of cosmeticallyacceptable anions.W denotes a radical chosen from the radicals: —SR₁₅, —S(O)R₁₅, —SO₂R₁₅,—SO₃H, —OSO₃H. Preferably, W represents an —SR₁₅ or —SO₃H radical.R₁₅ denotes an aromatic C5-C10, especially C5-C6 (hetero)cycle, 3 carbonatoms of which can be replaced by nitrogen atoms; a carbonyl radical—C(O)R₁₆; a radical —C(═NR₁₇)—NR₁₈R₁₉;R₁₆ denotes a linear or branched C1 to C6 alkyl radical;R₁₇, R₁₈, R₁₉ independently denote a hydrogen atom H or a linear orbranched C1-C6 alkyl radical;R₁₇ and R₁₈ may be connected to one another in order to form, with thenitrogen atoms to which they are attached, a saturated or unsaturatedring or bicyclic ring containing from 5 to 8 atoms.a1 and a2 are integers.a1=0 to 8, preferably 0 to 2.a2=0 or 1.(vi) a radical of formula (A5): —Y—(K)j-Gin which Y denotes a saturated or unsaturated, linear or branched C1 toC32 alkyl radical, optionally interrupted by 1 to 8 identical ordifferent groups chosen from —S—, S(O), SO₂, —NH— (or ═NH), —N═(trivalent), —O—, —C(O)—, —C(═NH)—, —N⁺(CH₃)₂-An⁻, a C6-C10, especiallyC6-C8 aryl (cyclic aromatic) radical, or combination thereof.

Preferably, Y denotes a saturated C2 to C8, more preferably C2, C4, C6alkyl radical;

K denotes a group chosen from —CO—, —NHC(O)—, —CH(NRR′)—, —CHR—,—C(═CHR)—.

Preferably, K denotes a group —CO— or —NHC(O)—, more preferably—NHC(O)—;

G denotes a group chosen from G1, G2 or G3, where:

-   -   G1 denotes a monosaccharide or a polysaccharide containing up to        20 sugar units, in pyranose and/or furanose form and of L and/or        D series, said monosaccharide or polysaccharide optionally        having one or more amine functions, the hydroxyl and amine        functions being optionally protected; and the optical and/or        geometric isomers thereof. Preferably, G1 represents a        monosaccharide or a polysaccharide containing up to 6 sugar        units, in pyranose and/or furanose form and of L and/or D        series. Advantageously, the preferred monosaccharides are chosen        from D-glucosamine, D-galactosamine, D-glucose, D-galactose,        D-mannose, D-xylose, D-lyxose, L-fucose, L-arabinose,        L-rhamnose, D-glucuronic acid, D-galacturonic acid, D-iduronic        acid, with a preference for D-glucosamine. These monosaccharides        may or may not be protected at the hydroxyl functions not        involved in the bond with the H radical. More advantageously,        the preferred polysaccharides containing up to 6 sugar units are        chosen from D-maltose, D-lactose, D-cellobiose, D-maltotriose, a        disaccharide combining a uronic acid chosen from D-iduronic acid        or D-glucuronic acid with a hexosamine chosen from        D-galactosamine, D-glucosamine, N-acetyl-D-galactosamine,        N-acetyl-D-glucosamine.    -   G2 denotes an alpha amino acid radical with a protected or        unprotected side chain, chosen from the side chains of the 22        natural amino acids, this radical being C or N branched, racemic        or non-racemic, of L or D stereochemistry, protected or        unprotected at the C or N residue and at the side chain for the        alpha amino acids in question. Preferably, the side chain is the        side chain of a cysteine, of a lysine, of an aspartic acid, of a        glutamic acid or of an arginine, more preferably a lysine.    -   G3 denotes a phenyl radical substituted at any one of the        positions with a hydroxyl radical and optionally substituted        with a group R₂₀. Preferably, G3 denotes an ortho-diphenol.

R₂₀ denotes a saturated or unsaturated, linear or branched C1 to C6alkyl radical, a C1 to C6 hydroxyalkyl radical, a C5-C10 aryl (cyclicaromatic) radical, or a radical —OH, —SH, —SO₃H, —COOH, —COOR, —NHC(O)R,NHC(O)OR, —NRR′ and —N⁺RR′R″ An⁻.

R, R′ and R″ independently denote a hydrogen atom H or a C1-C6 alkylradical, especially a methyl radical.

An⁻ denotes a cosmetically acceptable anion or a mixture of cosmeticallyacceptable anions.

j is an integer equal to 0 or 1.

Preferably, j=1 when G denotes a radical G1 and j=0 when G denotes aradical G2 or G3.

When G denotes a radical G1, and when G1 is connected to H by ananomeric bond, this anomeric bond may be α or β.

The protected hydroxyl or amine functions of monosaccharides or ofpolysaccharides are, for example, those obtained by the protectionreactions described in “Protective Groups in Organic Synthesis”, T. W.Greene, P. G. M. Wuts, second edition, Wiley Interscience, 1991.

(vii) a radical of formula (A6):—(CH₂)_(g)-(J)_(h)-(CH₂)_(i)—(CHR₂₃)_(k)—CH₂R₂₄

in which J denotes a group chosen from the groups: —S—, S(O), SO₂, —NH—(or ═NH), —N═ (trivalent), —O—, —C(O)—, —C(═NH)—, —N⁺(CH₃)₂— An⁻, aC6-C10, especially C6-C8, aryl (cyclic aromatic) radical, acarbon-carbon double bond, especially —CH═CH—, a carbon-carbon triplebond, or combinations thereof.

Preferably, J denotes a —NH—C(O)— group;

R₂₃ denotes a radical —OR₂₅, —SH, —SO₃H, —COOH, —COOR, —NHC(O)R,NHC(O)OR, —NRR′ and —N⁺RR′R″ An⁻, with R, R′ and R″=H or C1-C6 alkyl,especially methyl. Preferably, R₂₃ denotes a radical —OR₂₅;

R₂₄ denotes a hydrogen atom H, or a hydroxyl radical —OH;

R₂₅ denotes a hydrogen atom H, or a monosaccharide or a polysaccharidecontaining up to 20 sugar units, in pyranose and/or furanose form and ofL and/or D series, said monosaccharide or polysaccharide optionallyhaving one or more amine functions, the hydroxyl and amine functionsbeing optionally protected; and the optical and/or geometric isomersthereof. Preferably, R₂₅ represents a hydrogen atom or a monosaccharideor a polysaccharide containing up to 6 sugar units, in pyranose and/orfuranose form and of L and/or D series. Advantageously, the preferredmonosaccharides are chosen from D-glucosamine, D-galactosamine,D-glucose, D-galactose, D-mannose, D-xylose, D-lyxose, L-fucose,L-arabinose, L-rhamnose, D-glucuronic acid, D-galacturonic acid,D-iduronic acid, with a preference for glucose. These monosaccharidesmay or may not be protected at the hydroxyl functions not involved inthe bond with the radical —CH₂—R₂₄. More advantageously, the preferredpolysaccharides containing up to 6 sugar units are chosen fromD-maltose, D-lactose, D-cellobiose, D-maltotriose, a disaccharidecombining a uronic acid chosen from D-iduronic acid or D-glucuronic acidwith a hexosamine chosen from D-galactosamine, D-glucosamine,N-acetyl-D-galactosamine, N-acetyl-D-glucosamine.

An⁻ denotes a cosmetically acceptable anion or a mixture of cosmeticallyacceptable anions.

g, h, i, k denote an integer;

g, h, k=1 to 10;

i=0 to 10.

Preferably, g, h, k=1 to 6; i=0 to 3.

More preferably, g=4 to 6, h=1, k=4 to 6, i=0.

In the case where R₂₅ is connected to R₂₃ by an anomeric bond, thisanomeric bond may be α or β.

(viii) a radical of formula (A7): —(CH₂)_(b)-(A)-(B)-(A)_(c)-(CH₂)_(d)-D

in which A denotes a group chosen from —NHC(O)—, —C(O)NH—, —NHC(O)NH—,—C(O)O—, —OC(O)—;

B denotes a branched or unbranched hydrocarbon-based chain, optionallysubstituted with a radical chosen from —OH, —COOH, —NHC(O)R₂₁;

R₂₁ denotes a linear or branched C1-C6 alkyl radical;

D denotes a radical —SH or a linear or branched C1 to C4 alkyl radical.

b, c and d are integers;

b=2 to 10, preferably 3 to 6;

c=0 or 1;

d=0 to 10, preferably 0 to 3;

(ix) a radical of formula (A8): -Alk3-S—S-Alk4

in which Alk4 denotes a linear or branched C2 to C20 hydrocarbon-basedradical, optionally comprising one or more double bonds, and optionallycomprising one or more heteroatoms chosen from O or N, and optionallysubstituted with one or more identical or different radicals chosen from—OH, —SO₃H, —COOH, —COOR, —NHC(O)R, NHC(O)OR, —NRR′ and —N⁺RR′R″ An⁻.

Alk3 denotes a linear or branched C2 to C20 hydrocarbon-based radical,optionally comprising one or more double bonds, and optionallycomprising one or more heteroatoms chosen from O or N, and optionallysubstituted with one or more identical or different radicals chosen from—OH, —SO₃H, —COOH, —COOR, —NHC(O)R, —NRR′ and —N⁺RR′R″ An⁻.

R, R′ and R″ independently denote a hydrogen atom H or a linear orbranched C1-C6 alkyl radical, especially a tert-butyl or methyl radical.

An⁻ denotes a cosmetically acceptable anion or a mixture of cosmeticallyacceptable anions.

Preferably, Alk3 represents a linear or branched C2 to C10hydrocarbon-based chain, optionally interrupted by a group chosen from—NH—C(O)—O, —NH—C(O)—, —O—C(O)—.

More preferably still, Alk3 represents a linear C2 to C6hydrocarbon-based chain.

(x) a radical of formula (A9): —CHL-COOR₂₂

in which L denotes the side chain of an alpha amino acid, chosen fromthe side chains of the 22 natural amino acids; the stereochemistry is L,D or a racemic mixture. Preferably, the side chain is the side chain ofa lysine (—(CH₂)₄—NH₂), of a glutamic acid (—CH₂—CH₂—CO₂H) or of aglutamine (—CH₂—CH₂—CO—NH₂), protected or unprotected.

R₂₂ denotes a hydrogen atom H, or a linear or branched C1 to C6 alkylradical, or a benzyl radical.

Preferably, R₂₂ denotes a hydrogen atom H, or a tert-butyl radical.

(xi) a radical —(CH₂)₂—SH

(xii) a radical —(CH₂)₄—NH₂

According to a first variant, the compounds of formula (Ia) are suchthat Z denotes: a linear, saturated, non-cyclic C1 to C20hydrocarbon-based radical optionally substituted with 1 to 5 hydroxylradicals —OH, optionally interrupted by 1 to 5 identical or differentfunctional groups chosen from —NH—CO—NH—, —NHCO—, CO—NN—N⁺(CH3)₂—,terminated by a group chosen from —NR₁R₂, —N⁺R₁R₂R₃An⁻, —NHC(O)OR₄,—CH(NH₂)CO₂R₄, —NHC(O)CH(OH)(CH₂)₂OH,

in which:

R₁, R₂, R₃, independently represent a methyl or ethyl radical or anaminoalkyl, especially —(CH₂)₄—NH₂, radical.

R₄ represents a hydrogen atom H or a methyl, ethyl or tert-butylradical;

An⁻ denotes a cosmetically acceptable anion or a mixture of cosmeticallyacceptable anions.

According to a second variant, the compounds of formula (Ia) are suchthat Z denotes a radical (A1) in which n represents 0 or 1, X represents—NH—C(O)—NH—. p+q=4 to 10, it being understood that p+q≠5.

More preferably, according to this variant, n=0, p+q=4.

According to a third variant, the compounds of formula (Ia) are suchthat Z denotes a radical (A2) in which T represents a group —NH—C(O)—NH—or —NH—C(O)—O—, u=0, s=0 or 1, r, t and v are integers with r+t+vbetween 1 and 10, more preferably between 3 and 9.

R₁₀, R₁₁, R₁₂ are chosen independently from among the radicals OMe, OEt,OSiMe3, Me, Et,

it being understood that when s=u=0 and R₁₀=R₁₁=R₁₂=OR₁₃, then r+t+v≠3.

According to a fourth variant, the compounds of formula (Ia) are suchthat Z denotes a radical (A3) in which U denotes a carbon-carbon doublebond CH═CH, y is equal to 0 or 1 and x+z=15.

According to a fifth variant, the compounds of formula (Ia) are suchthat Z denotes a radical (A4) in which Alk1 and Alk2 independentlydenote a linear, saturated C1 to C10 alkyl radical.

V denotes a group chosen from the radicals —NH—C(O)—, NH—C(O)—O—,—N⁺(CH₃)₂-An⁻.

An⁻ denotes a cosmetically acceptable anion or a mixture of cosmeticallyacceptable anions.

W represents a radical —S—CO—CH₃ or —SO₃H or —S—C(═NH)NH₂.

a1=0 or 1.

a2=0 or 1.

According to a sixth variant, the compounds of formula (Ia) are suchthat Z denotes a radical (A5) in which Y denotes a linear, saturated C1to to C8, more preferably C2, C4, C6 alkyl radical;

K denotes a group —CO— or —NHC(O)—, more preferably —NHC(O)—;

j is equal to 0 or 1.

G denotes a group chosen from G1, G3, where:

-   -   G1 denotes a monosaccharide in pyranose and/or furanose form and        of L and/or D series, said monosaccharide optionally having one        or more amine functions, the hydroxyl and amine functions being        optionally protected; and the optical and/or geometric isomers        thereof. Advantageously, the preferred monosaccharides are        chosen from D-glucosamine, D-galactosamine, with a preference        for D-glucosamine. These monosaccharides may or may not be        protected at the hydroxyl functions not involved in the bond        with the H radical.    -   G3 denotes an ortho-diphenol radical.

Preferably, j=1 when G denotes a radical G1 and j=0 when G denotes aradical G3.

When G denotes a radical G1, and when G1 is connected to H by ananomeric bond, this anomeric bond may be α or β.

According to a seventh variant, the compounds of formula (Ia) are suchthat Z denotes a radical (A6) in which J denotes a group —NH—C(O)—;

R₂₃ denotes a radical —OR₂₅, —SH, —SO₃H, —COOH, —COOR, —NHC(O)R,NHC(O)OR, —NRR′ and —N⁺RR′R″ An⁻, with R, R′ and R″=H or C1-C6 alkyl,especially methyl. R₂₃ denotes a radical —OR₂₅.

R₂₄ denotes a hydrogen atom H, or a hydroxyl radical —OH, preferably ahydroxyl radical —OH.

R₂₅ denotes a hydrogen atom H, or a monosaccharide, in pyranose and/orfuranose form and of L and/or D series, said monosaccharide optionallyhaving one or more amine functions, the hydroxyl and amine functionsbeing optionally protected; and the optical and/or geometric isomersthereof. Preferably, R₂₅ represents a hydrogen atom or a monosaccharidein pyranose and/or furanose form and of L and/or D series.Advantageously, the preferred monosaccharides are chosen from D-glucose,D-galactose, D-mannose, D-xylose, D-lyxose, L-fucose, L-arabinose,L-rhamnose. These monosaccharides may or may not be protected at thehydroxyl functions not involved in the bond with the radical —CH₂—R₂₄.

More preferably, R₂₅ denotes a hydrogen atom or glucose.

g=4 to 6, h=1, k=4 to 6, i=0.

In the case where R₂₅ is connected to R₂₃ by an anomeric bond, thisanomeric bond may be α or β.

According to an eighth variant, the compounds of formula (Ia) are suchthat Z denotes a radical (A7) in which A denotes a group —NHC(O)—, Bdenotes a branched or unbranched hydrocarbon-based chain, optionallysubstituted by a radical chosen from —OH, —COOH, —NHC(O)R₂₁;

R₂₁ denotes a linear or branched C1 to C4 alkyl radical, preferably amethyl radical;

D denotes an —SH radical or a linear or branched C1 to C4 alkyl radical,preferably an —SH radical or a methyl radical.

b=3 to 6;

c=0 or 1, preferably c=0;

d=0 to 3.

According to a ninth variant, the compounds of formula (Ia) are suchthat Z denotes a radical (A8) in which Alk4 denotes a linear C2 to C10hydrocarbon-based radical, optionally substituted with one or moreidentical or different radicals chosen from —COOR, —NHC(O)R, NHC(O)OR,preferably NH—C(O)—OR.

Alk3 denotes a linear C2 to C6 hydrocarbon-based radical.

R denotes a hydrogen atom H or a linear or branched C1-C4 alkyl radical,especially a tert-butyl or methyl radical.

According to a tenth variant, the compounds of formula (Ia) are suchthat Z denotes a radical (A9) in which L denotes the side chain of alysine (—(CH₂)₄—NH₂), of a glutamic acid (—CH₂—CH₂—CO₂H) or of aglutamine (—CH₂—CH₂—CO—NH₂), protected or unprotected, the amino acidprecursor being D or L or racemic.

R₂₂ denotes a hydrogen atom H, or a linear or branched C1 to C6 alkylradical, or a benzyl radical. Preferably, R₂₂ denotes a hydrogen atom H,or a tert-butyl radical.

Preferably, the compounds of formula (I) are the following:

Definition of an N-branched amino acid: —NH—CHL-COP, with L representingthe side chain and P being equal to —OH or an acid-protecting group suchas an alcohol or an amine.

Definition of a C-branched amino acid: —C(O)—CHL-NHP, with Lrepresenting the side chain and P equal to —H or an amine-protectinggroup such as the group —NHP which represents an amide, a urea, acarbamate, a guanidine.

The compounds of formula (I) may be prepared according to any knownmethod.

If the reference A is given to the group below:

the compounds according to the invention may be representedschematically as: A-Z.

They may be obtained during the reaction:

-   -   between a reactive function bonded to the group A with a        reactive function borne by the group Z; or else    -   between a reactive function bonded to a precursor of the group A        with a reactive function borne by the group Z in order to        simultaneously form the group A and the entity A-Z;        the two reactive functions of course being capable of reacting        with one another, and possibly being bonded directly or via a        divalent segment to the group A, to the group Z and/or to the        precursor of said group A.

The reactive functions may preferably be chosen from the followingfunctions:

-   -   isocyanate —N═C═O;    -   isothiocyanate —N═C═S;    -   carboxylic acid or ester —COOR_(a) with R_(a)=H or a linear or        branched C1-C12, preferably C1-C4 alkyl, better still methyl or        ethyl, radical;    -   activated ester COOR_(b) with OR_(b) chosen from phenoxy,        4-nitrophenoxy, 2,4,5-trichlorophenoxy and the following        radicals:

-   -   acyl halide,    -   acyl imidazole or acyl benzotriazole of formula:

-   -   acid anhydride;    -   activated carbamic acid —NHCOX with X=Cl, imidazole or OR_(b)        with OR_(b) as defined above;    -   hydroxyl (OH) or activated hydroxyl, for example in O-tosylate        form;    -   primary or secondary amine —N(R_(a))₂, where the R_(a) groups,        which are identical or different, are as defined above;    -   a function chosen from:

with R_(a), which may be identical or different, being as defined above.

Preferably, the reactive functions that are a precursor of the bondbetween Z and A are chosen from isocyanate, amine or hydroxyl functionsor functions of formula:

One particular method for obtaining the compounds according to theinvention is described in the article by Katritzky et al., ComprehensiveOrganic Functional Group Transformations, Pergamon, Oxford, 1995, vol.6, pp. 500-506 or else in Arkiv der Pharmazie, 314(1), 34-41, 1981.

It is in particular possible to react:

-   -   an isocytosine with an activated carbamic acid:

-   -   an isocytosine with an amine-derived isocyanate:

-   -   an isocytosine containing an activated carbamic function with an        amine:

-   -   a β-keto ester with a guanylalkylurea derivative:

Another method for preparing the compounds according to the inventionconsists in synthesizing a compound of the following type:

and then reacting it with an alcohol or an amine.

In this formula, the divalent group R′1 represents, for example, a groupchosen from: 1,2-ethylene, 1,6-hexylene, 1,4-butylene,1,6-(2,4,4-trimethylhexylene); 1,4-(4-methylpentylene),1,5-(5-methylhexylene), 1,6-(6-methylheptylene);1,5-(2,2,5-trimethylhexylene), 1,7-(3,7-dimethyloctylene); isophorone;4,4′-methylene-biscyclohexylene, tolylene, 2-methyl-1,3-phenylene;4-methyl-1,3-phenylene; 4,4-biphenylenemethylene; and preferablyisophorone; —(CH₂)₂—; —(CH₂)₆—; —CH₂CH(CH₃)—CH₂—C(CH₃)₂—CH₂—CH₂;4,4′-methylenebiscyclohexylene; 2-methyl-1,3-phenylene. Better still,R′₁=isophorone or 1,6-hexylene.

Preferably, R1=H and R2=methyl.

Particularly preferably, the compounds of formula (I) are soluble ordispersible in water or soluble in water basified using a 28% aqueousammonia solution (the pH of the solution is then between 8 and 10), orsoluble in water acidified using citric acid.

The term “soluble” is understood to mean that the compound forms a clearsolution, at a concentration of 0.1% by weight in the medium, at 25° C.and 1 atm. The term “dispersible” is understood to mean that thecompound forms, in the medium, at a concentration of 0.1% by weight at25° C. and 1 atm., a stable suspension or dispersion of fine particles,which are generally spherical. The term “stable” is understood to meanthat the suspension does not precipitate and does not therefore displayany visible deposit. The mean size of the particles constituting thesuspension or the dispersion is preferably less than 1 μm, and moregenerally ranges between 5 and 400 nm, preferably 10 to 250 nm. Theseparticle sizes are measured by any conventional light scattering method.

The compounds according to the invention find a very particularapplication in the field of cosmetics, especially in the field ofhaircare.

The amount of compound present in the cosmetic compositions according tothe invention depends, of course, on the type of composition and on thedesired properties, and can vary within a very wide range, generallybetween 0.001% and 30% by weight, preferably between 0.005% and 15% byweight, in particular between 0.01% and 10% by weight, or even between0.1% and 5% by weight, relative to the total weight of the composition.

The cosmetic compositions can of course comprise a mixture of compoundsof formula (I).

In one particular embodiment of the invention, the cosmetic compositionsmay comprise, besides the compounds of formula (I), compounds of formula(II) as defined below.

Specifically, it has been noted that when a mixture of compounds (I) andcompounds (II) is used, a modification of the mechanical properties ofthe hair is observed, which may be an increase or decrease in theirrigidity, depending on the nature of the compounds used.

Preferably, the compositions may comprise the compounds (II), alone oras a mixture, in an amount between 0.001% and 30% by weight, preferablybetween 0.005% and 15% by weight, especially between 0.01% and 10% byweight, or even between 0.1% and 5% by weight, relative to the totalweight of the composition.

The additional compounds therefore correspond to the formula (II):

in which:

-   -   n=1 or 2, and    -   Z represents a divalent or trivalent (depending on the value of        n), linear or branched C1-C32 alkyl or C2-C32 alkenyl radical;        preferably a C2-C18, especially a C3-C12 radical;        optionally substituted with 1 to 10, especially 2 to 8, or even        3 to 6 radicals chosen from —OH, —SO₃H, —COOH, —COOR and        —N⁺RR′R″, with R, R′ and R″=C1-C12 alkyl, especially methyl;        and/or        optionally interrupted by 1 to 10, especially 2 to 8, or even 3        to 6 groups chosen from (i) the divalent groups: —S—, —NH— (or        ═NH), —O—, —C(O)—, or of formula:

with Ra=H or halogen, especially Cl, or C1-C6 alkyl, or single bond, andR′ and R″, which may be identical or different, representing a hydrogenatom or a C1-C6 alkyl radical, especially methyl; and

-   -   (ii) the trivalent groups of formula:

R′ representing a hydrogen atom or a C1-C6 alkyl radical, especiallymethyl; said trivalent groups generally being present at the junction ofsaid radicals.

Among the compounds of formula (II) capable of being used, mention maybe made of the following compounds:

The compositions according to the invention may be in any of the galenicforms conventionally used, and in particular in the form of an aqueous,alcoholic or aqueous-alcoholic, or oily solution or suspension; asolution or a dispersion of the lotion or serum type; an emulsion, inparticular of liquid or semi-liquid consistency, of the O/W, W/O ormultiple type; a suspension or emulsion of soft consistency of cream(O/W) or (W/O) type; an aqueous or anhydrous gel, or any other cosmeticform. Preferably, the composition is in the form of an aqueoussuspension, serum or lotion.

These compositions may be packaged, especially in pump bottles or inaerosol containers, so as to apply the composition in vaporized form orin the form of a mousse. Such packaging forms are indicated, forexample, when it is desired to obtain a spray or a mousse, for treatingthe hair. In these cases, the composition preferably comprises at leastone propellant.

The compositions according to the invention comprise a cosmeticallyacceptable medium, i.e. a medium that is compatible with keratinmaterials, in particular the skin of the face or of the body, the lips,the hair, the eyelashes, the eyebrows and the nails.

Said medium preferably comprises at least one customary cosmeticingredient, in particular chosen from propellants; carbon-based oils;silicone oils; C8-C40 alcohols, C8-C40 esters, C8-C40 acids; nonionicsurfactants, cationic surfactants, anionic surfactants, amphotericsurfactants, zwitterionic surfactants; sunscreens; moisturizers;antidandruff agents; antioxidants; reducing agents; oxidation bases,couplers, oxidizing agents, direct dyes; hair straightening agents,pearlescent agents and opacifying agents; plasticizers or coalescenceagents; hydroxy acids; pigments; fillers; polyols; waxes; thickeners,emulsifiers; polymers; preservatives.

Said medium may also comprise an additional ingredient chosen fromwater, C1-C7 alcohols, ketones, organic solvents, silicones; waxes; pHagents.

Said medium can of course comprise several cosmetic ingredientsappearing in the lists above.

Depending on their nature and the purpose of the composition, theingredients may be present in normal amounts, which can be readilydetermined by a person skilled in the art, and which may be, for eachingredient, between 0.01% and 80% by weight.

In one particular embodiment, the composition according to the inventionmay comprise one or more reducing agents, which may be chosen fromthiols, for example cysteine, homocysteine, thiolactic acid, salts ofthese thiols, phosphines, bisulphite, sulphites, thioglycolic acid, andalso esters thereof, especially glyceryl monothioglycolate, andthioglycerol. This reducing agent may also be chosen from borohydridesand derivatives thereof, such as for example borohydride,cyanoborohydride, triacetoxyborohydride and trimethoxyborohydride salts;sodium, lithium, potassium, calcium and quaternary ammonium(tetramethylammonium, tetraethylammonium, tetra-n-butylammonium,benzyltriethylammonium) salts; catecholborane; and mixtures thereof.

The composition may especially comprise water, one or more C1-C7alcohols, alone or as a mixture with water, and especially awater/ethanol, water/isopropanol or water/benzyl alcohol mixture.

The carbon-based, in particular hydrocarbon-based, oils and/or thesilicone oils may be present in a proportion of from 0.01% to 20% byweight relative to the total weight of the composition. Mention mayespecially be made of hydrogenated or non-hydrogenated plant, animal ormineral oils, saturated or unsaturated, linear or branched, cyclic oraliphatic, hydrocarbon-based synthetic oils, for instancepoly(alpha-olefin)s, in particular polydecenes and polyisobutenes;water-soluble or water-insoluble, organomodified or non-organomodified,volatile or non-volatile silicone oils; fluoro or perfluoro oils;mixtures thereof.

The alcohols, the esters and the acids, having 8 to 40 carbon atoms, maybe present in a proportion of from 0.01% to 50% by weight, especially0.1% to 20% by weight, relative to the total weight of the composition.

Mention may especially be made of C12-C32, especially C12-C26,linear-chain or branched-chain fatty alcohols, and in particular cetylalcohol, stearyl alcohol, cetylstearyl alcohol, isostearyl alcohol,octyldodecanol, 2-butyloctanol, 2-hexyldecanol, 2-undecylpentadecanol,oleyl alcohol or linoleyl alcohol. Mention may also be made ofalkoxylated, in particular ethoxylated, C8-C40, especially C16-C20 fattyalcohols, preferably comprising from 10 to 50 mol of ethylene oxideand/or of propylene oxide, such as oleth-12, ceteareth-12 andceteareth-20, oxypropylenated stearyl alcohol, especially comprising 15mol of propylene oxide, oxyethylenated lauryl alcohol, especiallycomprising more than 7 oxyethylenated groups, and also mixtures thereof.Mention may also be made of C16-C40 linear-chain or branched-chain fattyacids, and especially 18 methyleicosanoic acid, coconut oil orhydrogenated coconut oil acids; stearic acid, lauric acid, palmitic acidand oleic acid, behenic acid, and mixtures thereof. Mention may also bemade of C16-C40 linear-chain or branched-chain fatty esters, such asesters of polyols derived from fatty acids containing from 8 to 30carbon atoms, and the oxyalkylenated, and especially oxyethylenated,derivatives thereof, the polyols preferably being chosen from sugars,C2-C6 alkylene glycols, glycerol, polyglycerols, sorbitol, sorbitan,polyethylene glycols, polypropylene glycols, and mixtures thereof.

The silicones may be volatile or non-volatile; mention may especially bemade of modified or unmodified polyorganosiloxanes, i.e.polyorganosiloxane oils, gums and resins, as they are or in the form ofsolutions in organic solvents, or in the form of emulsions ormicroemulsions.

A person skilled in the art will take care to choose the ingredientswhich are part of the composition, and also the amounts thereof, in sucha way that they are not detrimental to the properties of thecompositions of the present invention.

The cosmetic composition according to the invention may be in the formof a care, cleansing and/or makeup product for the skin of the body orthe face, the lips, the eyebrows, the eyelashes, the nails and the hair,a suntan or self-tanning product, a body hygiene product, a hairproduct, especially a hair care, cleansing, conditioning or dyeingproduct. It especially has a particularly advantageous application inthe hair-related field, especially for caring for, cosmetically treatingor cleansing the hair.

The hair compositions are preferably shampoos, cream rinses, care gels,lotions or creams, conditioners, hair restructuring lotions; lotions orgels for combating hair loss, antiparasitic shampoos, antidandrufflotions or shampoos, or shampoos for treating seborrhoea. They may alsobe a hair dyeing product, especially an oxidation dyeing product,optionally in the form of a dye shampoo; in the form of apermanent-waving, hair-straightening or bleaching composition, or elsein the form of a rinse-out or leave-in composition, to be applied beforeor after dyeing, bleaching, permanent-waving or hair-straightening, orelse between the two steps of a permanent-waving or hair-straighteningoperation.

The composition according to the invention has an advantageousapplication in the care and the cosmetic treatment, especially theprotection, of the hair, in particular weakened and/or damaged hair, forexample hair weakened and/or damaged by chemical or mechanicaltreatments; use may especially be made of the compounds according to theinvention in post-treatment, after a hair dyeing, bleaching orstraightening step.

One subject of the invention is therefore a method for cosmeticallytreating, in particular for making up, caring for, cleansing or dyeingkeratin materials, especially the skin of the body or of the face, thelips, the nails, the hair and/or the eyelashes, comprising theapplication of a cosmetic composition comprising at least one compoundaccording to the invention to said materials.

Preferably, it is a cosmetic treatment method for conditioning and/orcaring for the hair, in particular for giving it body and/or liveliness,or improving the disentangling, smoothing, combability, repair andmanageability of the head of hair. It may be a method for repairingand/or protecting damaged or weakened hair.

In one particular embodiment of the treatment method, the compositionaccording to the invention may be applied all at once, or in severalapplications (multi-application).

Thus, it is possible to apply a composition comprising the compoundsaccording to the invention, in an amount, for example, of from 0.05% to15%, especially 0.1% to 5% by weight, to the hair a first time, to leaveit in for 2 to 20, especially 5 to 15, minutes, optionally while heatingat a temperature below 65° C., or else with a smoothing iron or acrimping iron, for example for a few seconds, and then, optionally, todry the hair before applying the composition a second time, and to againleave it in for 2 to 20, especially 10, minutes, before optionallyheating at a temperature below 65° C., or else with a smoothing iron ora crimping iron, for example for a few seconds, and then to dry or allowto dry. It is possible to carry out a third application of thecomposition. This multi-application of the composition may especiallymake it possible to improve the penetration of the compounds inside thehair, and therefore to improve the repair of the hair in situ.

As well as that indicated above, the compounds according to theinvention have a very particular use in a cosmetic hair treatmentmethod, before, during or after a cosmetic hair dyeing, bleaching,permanent-waving, straightening or smoothing treatment; they also havean application in a maintenance method for damaged hair, especially hairdamaged by external attacks such as UV, pollution, repeated brushing andchlorinated water.

The expression “during a treatment” is understood to mean use as amixture with one or other of the elements of the treatment kit orbetween the various steps of a treatment, for example a permanent-wavingtreatment.

Thus, another subject of the invention is a kit comprising, on the onehand, a composition for dyeing, bleaching, permanent waving,straightening or smoothing the hair and, on the other hand, a cosmeticcomposition comprising at least one compound of formula (I).

The two compositions may be applied one after the other, with optionalrinsing between the two applications; they may also be mixed just beforeuse and application of the mixture. A subsequent rinsing and/or dryingstep may be envisaged.

In one particular embodiment, one of the compositions of the kitcomprises at least one reducing agent, in particular chosen from thelist given above; the reducing agent may especially be present in thehair dyeing, bleaching, permanent-waving, straightening or smoothingcomposition, the compound of formula (I) being present in the othercomposition of the kit.

The invention is illustrated in greater detail in the followingexemplary embodiments.

EXAMPLE 1:N-(4-aminobutyl)-N′-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureahydrochloride (1) 1/ Preparation oftert-butyl[4-({[(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)amino]carbonyl}amino)butyl]carbamate(1B) from isocytosine having a carbamic function activated bycarbonyldiimidazole (1A) (procedure no. 1)

Added to a solution of 1.72 g of tert-butyl(4-aminobutyl)carbamate (9.1mmol) in 50 ml of dichloromethane, are 2 g of2-(1-imidazolylcarbonylamino)-6-methyl-4[1H]-pyrimidinone 1A (9.1 mmol)prepared according to the procedure described by E. W. Meijer et al., J.Am. Chem. Soc., 2003, 125, p. 6860. The solution is stirred at refluxfor 4 hours. The end product is obtained by precipitation in acetone.After filtering and washing with acetone, the end product is dried underreduced pressure and 4.02 g (11.8 mmol) of pure product 1B are obtainedin the form of a white powder with a yield of greater than 99%(hygroscopic product).

¹H NMR (DMSO): δ 1.37 ppm (s, 9H), 2.11 ppm (s, 3H), 2.88-2.96 ppm (m,2H), 3.09-3.16 ppm (m, 2H), 3.17-3.20 ppm (m, 4H), 4.07-4.13 ppm (m,1H).

2/ Preparation ofN-(4-aminobutyl)-N′-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureahydrochloride (1) (procedure no. 2)

Added to a solution of 3.02 g oftert-butyl[4-({[(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)amino]carbonyl}amino)butyl]carbamate(8.9 mmol) prepared above, in 10 ml of ethyl acetate, are 9.28 g of 35%hydrochloric acid (89.5 mmol). The solution is stirred at 5° C. for 1hour. The end product is obtained by precipitation in acetone. Afterfiltering and washing with acetone, the end product is dried underreduced pressure and 2.28 g (9.5 mmol) of desired product (1) areobtained in the form of a white powder with a yield of greater than 99%(hygroscopic product).

Melting point: 131° C.

¹H NMR (DMSO): δ 1.30-1.78 ppm (m, 4H), 2.23 ppm (s, 3H), 2.73-2.87 ppm(m, 2H), 3.10-3.25 ppm (m, 2H), 6.04 ppm (m, 1H).

EXAMPLE 2:N-[3-(dimethylamino)propyl]-N′-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)urea(2)

Preparation from 6-methylisocytosine (2A) and carbonyldiimidazole (2B):

Added to a suspension of 5 g of 6-methylisocytosine (40 mmol) in 100 mlof ethyl acetate are 8.42 g of carbonyldiimidazole (52 mmol). Thesolution is stirred for 12 hours at reflux, then 8 hours at roomtemperature. 5.03 ml of dimethylaminopropylamine (40 mmol) are added.The solution is stirred for 6 hours at reflux. The end product isobtained by filtration on a Büchner funnel. The end product is driedunder reduced pressure and 9.6 g (38 mmol) of desired product areobtained in the form of a white powder with a yield of 95%.

¹H NMR (DMSO): δ 1.77 ppm (t, 2H), 2.19 ppm (s, 3h), 2.71 ppm (s, 6H),3.28 ppm (t, 2H), 5.84 ppm (s, 1H).

EXAMPLE 3:trimethyl-{3-[3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureido]-propyl}ammoniumchloride (3)

Preparation from isocytosine having a carbamic function activated bycarbonyldiimidazole:

The product is prepared according to procedure no. 1 described inExample 1.

6 g (20.2 mmol) of pure desired product are obtained in the form of awhite powder with a yield of 69%.

Melting point: 143.49° C.

¹H NMR (D₂O): δ 1.97-2.07 ppm (m, 2H), 2.17-2.22 ppm (m, 3H), 3.05-3.08ppm (m, 9H), 3.10-3.13 ppm (m, 2H), 3.26-3.32 ppm (m, 3H), 3.33-3.37 ppm(m, 2H), 5.86-5.98 ppm (m, 2H).

EXAMPLE 4:1-[3-(dimethylamino)propyl]-3-(6-{[(6-methyl-4-oxo-1,4-dihydro-pyrimidin-2-yl)carbamoyl]amino}hexyl)urea(4)

Preparation from isocytosine having an isocyanate function:

The product is prepared according to procedure no. 1 described inExample 1, from1-(6-isocyanatohexyl)-3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureaprepared according to the procedure described by E. W. Meijer et al., J.Am. Chem. Soc., 2003, 125, p. 6860.

6.2 g (15.7 mmol) of pure desired product are obtained in the form of awhite powder with a yield of 92%.

¹H NMR (DMSO+TFA): δ 1.37 ppm (m, 8H); 1.76 ppm (t, 2H); 2.25 ppm (s,3H); 2.74 ppm (d, 6H); 3.07 ppm (m, 8H); 6.03 ppm (s, 1H).

EXAMPLE 5:N-(4-{[amino(imino)methyl]amino}butyl)-N′-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)urea(5)

Preparation from isocytosine having a carbamic function activated bycarbonyldiimidazole (1A):

The product is prepared according to procedure no. 1.

5.8 g (20.6 mmol) of pure desired product are obtained in the form of awhite powder with a yield of 47%.

Melting point: 197.1° C.

¹H NMR (DMSO+CD₃COOD): δ 1.48 ppm (m, 4H); 2.14 ppm (m, 3H); 3.11-3.17ppm (m, 4H); 5.84 ppm (m, 1H).

EXAMPLE 6:1-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-3-octadec-9-enylurea (6)

Preparation from isocytosine having a carbamic function activated bycarbonyldiimidazole 1A:

The product is prepared according to procedure no. 1.

4.2 g (10 mmol) of pure desired product are obtained in the form of awhite powder with a yield of 73%.

Melting point: 114.4° C.

¹H NMR (DMSO): δ 0.85-0.91 ppm (m, 3H), 1.18-1.39 ppm (m, 24H),1.54-1.64 ppm (m, 2H), 1.94-2.05 ppm (m, 2H), 2.14-2.39 ppm (m, 3H),3.15-3.43 ppm (m, 2H), 5.20-5.55 ppm (m, 2H), 5.67-5.97 ppm (m, 1H).

EXAMPLE 7:(2S)-6-amino-2-({[(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-amino]carbonyl}amino)hexanoicacid (7) 1/ Preparation oftert-butyl(2S)-6-[(tert-butoxycarbonyl)amino]-2-({[(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)amino]carbonyl}amino)hexanoate(7A) from isocytosine having a carbamic function activated bycarbonyldiimidazole (1A)

The product (7A) is prepared according to procedure no. 1.

4.6 g (10.1 mmol) of pure desired product are obtained in the form of awhite powder with a yield of 69%.

¹H NMR (DMSO): δ 1.26 ppm (m, 2H); 1.37 ppm (s, 9H); 1.42 ppm (s, 9H);1.65 ppm (m, 2H); 2.13 ppm (s, 3H); 2.89-2.91 ppm (q, 2H); 4.14-4.15 ppm(m, 1H); 5.81 ppm (s, 1H).

2/ Preparation of Desired Product (7) from (7A)

The desired product (7) is prepared according to procedure no. 2described in Example 2.

4.5 g (15.2 mmol) of pure product are obtained in the form of a whitepowder with a yield >99%.

¹H NMR (DMSO): δ 1.39 ppm (m, 2H); 1.56-1.58 ppm (m, 2H); 1.90 ppm (m,2H); 2.18 ppm (s, 3H); 2.75 ppm (m, 2H); 4.19-4.20 ppm (d, 1H); 5.93 ppm(s, 1H).

EXAMPLE 8:(2S)-2-({[(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)amino]-carbonyl}amino)pentanedioicacid (8) 1/ Preparation ofdi-tert-butyl(2S)-2-({[(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-amino]carbonyl}amino)pentanedioate(8A) from isocytosine having a carbamic function activated bycarbonyldiimidazole (1A)

The product (8A) is prepared according to procedure no. 1.

11.7 g (28.5 mmol) of pure product (8A) are obtained in the form of awhite powder with a yield >99%.

¹H NMR (DMSO): δ 1.38-1.46 ppm (d, 18H); 1.78-1.86 ppm (m, 1H),1.78-1.86 ppm (m, 1H); 2.14 ppm (s, 3H); 2.24-2.31 ppm (m, 2H);4.17-4.27 ppm (m, 1H); 5.82 ppm (s, 1H).

2/ Preparation of(2S)-2-({[(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)amino]-carbonyl}amino)pentanedioicacid (8)

The product is prepared according to procedure no. 2.

9.8 g (32.9 mmol) of pure product (8) are obtained in the form of awhite powder with a yield >99%.

¹H NMR (D₂O): δ 2.05 ppm (m, 1H); 2.24 ppm (m, 1H); 2.27 ppm (s, 3H);2.5 ppm (m, 2H); 4.42-4.43 ppm (m, 1H); 6.04 ppm (s, 1H).

EXAMPLE 9:(2R,3R,4R,5R)-2,3,5,6-tetrahydroxy-N-4-{[(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)carbamoyl]amino}butyl)-4-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}hexanamide(10)

Preparation of (10) fromN-(4-aminobutyl)-N′-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureahydrochloride (1) (procedure no. 3):

Added to a suspension of 0.5 g of lactobionic acid (1.4 mmol) in 40 mlof ethanol are 0.35 g ofN-(4-aminobutyl)-N′-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureahydrochloride (1.27 mmol) and 0.32 g of diisopropylethylamine (2.56mmol). The solution is stirred for 6 hours at reflux. The end product isobtained by reverse-phase purification, eluting with acetonitrile/water5/5 with 0.2% of trifluoroacetic acid.

0.45 g (0.78 mmol) of pure product (10) is obtained in the form of awhite powder with a yield of 62%.

¹H NMR (DMSO): δ 1.47 ppm (m, 4H); 2.12 ppm (s, 3H); 3.12 ppm (m, 4H);3.25-4.36 ppm (m, 13H); 5.78 ppm (s, 1H).

EXAMPLE 10:(2-{2-[3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureido]ethyl-disulphanyl}ethyl)carbamicacid tert-butyl ester (11)

Preparation of (11) from isocytosine having a carbamic functionactivated by carbonyldiimidazole (1A):

The product (11) is prepared according to procedure no. 1.

4.8 g (10 mmol) of pure product (11) are obtained in the form of a whitepowder with a yield of 86%.

Melting point: 182.15° C.

¹H NMR (DMSO): δ 1.31-1.45 ppm (s, 9H), 2.11-2.14 ppm (m, 3H), 2.73-2.81ppm (m, 2H), 2.81-2.90 ppm (m, 2H), 3.15-3.26 ppm (m, 2H), 3.41-3.51 ppm(m, 2H), 5.76-5.81 ppm (m, 1H).

EXAMPLE 11:4-[(4-{[(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)carbamoyl]-amino}butyl)amino]-4-oxobutylimidothiocarbamate hydrochloride (12) 1/ Preparation of4-chloro-N-(4-{[(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-carbamoyl]amino}butyl)butanamide(12A) fromN-(4-aminobutyl)-N′-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureahydrochloride (1)

Added to a solution of 20 g ofN-(4-aminobutyl)-N′-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureahydrochloride (1) (70 mmol) in 200 ml of water cooled to 0° C. are 11.6g of sodium hydroxide (0.29 mol) and 24.4 ml of chlorobutyl chloride(0.22 mol). The solution is stirred for 18 hours at room temperature.The product obtained is filtered and then dried under reduced pressure.

14.2 g (41.4 mmol) of pure product (12A) are obtained in the form of awhite powder with a yield of 54%.

¹H NMR (DMSO): δ 1.41 ppm (s, 4H); 1.93 ppm (m, 2H); 2.10 ppm (s, 3H);2.20 ppm (t, 2H); 3.09 ppm (m, 2H); 3.62 ppm (m, 2H); 5.79 ppm (s, 1H).

2/ Preparation of (12) from4-chloro-N-(4-{[(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)carbamoyl]amino}butyl)butanamide(12A)

Added to a solution of 10.7 g of4-chloro-N-(4-{[(6-methyl-4-oxo-1,4-dihydro-pyrimidin-2-yl)carbamoyl]amino}butyl)butanamide(12A) (3 mmol) in 100 ml of 2-propanol are 2.84 g of thiourea (4 mmol).The solution is stirred for 17 hours at reflux. The product obtained isfiltered and then dried under reduced pressure.

10.7 g (25.5 mmol) of pure product (12) are obtained in the form of ayellow powder with a yield of 82%.

¹H NMR (DMSO): δ 1.44 ppm (t, 4H); 1.83 ppm (q, 2H); 2.09 ppm (s, 3H);2.24 ppm (t, 2H); 3.11 ppm (m, 6H); 5.76 ppm (s, 1H).

EXAMPLE 12:1-[2-(3,4-dihydroxyphenyl)ethyl]-3-(6-methyl-4-oxo-1,4-dihydro-pyrimidin-2-yl)urea(13)

Preparation of (13) from isocytosine having a carbamic functionactivated by carbonyldiimidazole (1A):

The product is prepared according to procedure no. 1.

11.1 g (36.5 mmol) of pure product (13) are obtained in the form of awhite powder with a yield of 80%.

Melting point: 266.28° C.

¹H NMR (DMSO): δ 1.95-2.15 ppm (s, 3H); 2.52-2.62 ppm (t, 2H); 5.76 ppm(s, 1H); 3.33 ppm (t, 2H); 6.46-6.66 ppm (m, 3H).

EXAMPLE 13: Improvement of Hair Straightening

Applied to hair (originally curly hair of curliness IV) straightened byan alkaline hair-straightening product (Goldys—2% active sodiumhydroxide) is the following composition, with an amount ofproduct/amount of hair ratio (g/g) of 2, without rinsing:

-   -   5% by weight of compound (2) from Example 2    -   qs for 100% distilled water

Observations are made at T0.

The locks are then washed once or 5 times using Ultra Mild shampoo(Garnier), then dried. Observations are made at T1 (after 1 shampoowash) and at T5 (after 5 shampoo washes).

The control locks are treated with a composition comprising 100%distilled water.

It is observed that with a treatment according to the invention, at T0,the hair-straightening efficiency is improved compared to ahair-straightening operation that has been subjected to the controlpost-treatment (only constituted of distilled water). This improvementin the hair-straightening efficiency persists after 1 and 5 shampoowashes.

A porosity measurement of the various locks of hair using a fluorescentprobe shows that the improvement in the hair-straightening efficiency atT0 is not accompanied by an increase of the internal porosity of thehair: indeed, the control hair and the hair post-treated according tothe invention have an equivalent porosity, after 5 shampoo washes.

Via a post-treatment according to the invention, on hair straightenedusing sodium hydroxide, it is possible to obtain hair-straighteningperformances superior to those obtained without treatment, withoutdamaging the fibre further.

EXAMPLE 14: Reduction of the Concentration of Alkaline Agent in theHair-Straightening Formulation

The composition from Example 14 is applied as post-treatment for ahair-straightening formula containing 1.75% by weight of sodiumhydroxide (i.e. a reduction of 0.25% of sodium hydroxide compared to astandard hair-straightening formula containing 2% of sodium hydroxide).

Identical hair-straightening performances are observed at T0 between:

-   -   the standard hair-straightening formula (2% sodium hydroxide),        without post-treatment and    -   the hair-straightening formula with a lower sodium hydroxide        concentration (1.75% of sodium hydroxide), the application of        which is followed by the post-treatment with the composition        from Example 14.

EXAMPLE 15

Application of a (14)+(1) mixture to locks of sensitized hair.

AM: active material

1/ Preparation of the Solution

The following are mixed:

-   -   30 mg of        N,N″-[(methylimino)dipropane-3,1-diyl]bis[N′-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)urea] (14)        (0.06 mmol) and    -   3 mg of        1-(4-aminobutyl)-3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)urea        hydrochloride (0.12 mol) (1) prepared in Example 1,    -   in 29.94 ml of water.

The mixture is stirred vigorously for 30 minutes at room temperature. Acolourless translucent solution is obtained.

2/ Application to Hair

The tests are carried out on 1 g locks of sensitized hair.

The hair is wetted with water, shampooed with 0.4 g of shampooconstituted of 15% sodium lauryl sulphate in water, and then rinsed.

The hair is pretreated with 10 ml of a 0.2N reducing solution ofthioglycolic acid for 15 minutes at 30° C. The hair is then rinsed withwater.

The hair undergoes the following post-treatment, repeated three times:10 ml of solution prepared above are applied to the lock of hair for 10minutes at 60° C. The lock is then wrung out and then left for 10minutes at room temperature.

A significant increase in the rigidity of the lock post-treatedaccording to the invention (around 15% increase), compared with acontrol lock, post-treated with water, is observed.

EXAMPLE 16

In a comparable manner to Example 15, a post-treatment is applied usinga composition comprising the compound (5) prepared in Example 5, insteadof the compound (1).

A significant increase in the rigidity of the lock post-treatedaccording to the invention (around 23% increase), compared with acontrol lock, post-treated with water, is observed.

EXAMPLE 17

In a comparable manner to Example 15, a post-treatment is applied usinga composition comprising the compound (15) instead of the compound (14).

A significant increase in the rigidity of the lock post-treatedaccording to the invention (around 33% increase), compared with acontrol lock, post-treated with water, is observed.

The invention claimed is:
 1. A cosmetic composition comprising, in aphysiologically acceptable medium, at least one compound of formula (I),salts thereof, and the tautomeric forms thereof:

in which: R1 and R2, independently of one another, represent H, —OH,—NRR′ with R, R′, which may be identical or different, being H or alinear or branched C1-C12 alkyl radical; or a carbon-based group; Zrepresents a monovalent radical selected from the group consisting of:(i) a hydrogen atom, (ii) a linear or branched C1 to C32 (saturated)alkyl radical; (iii) a linear or branched C2 to C32 (unsaturated) alkeneradical, comprising one or two C=C double bonds; (iv) a C1-C32 alkylradical, substituted with a C6-C10 aryl; and wherein each of (ii), (iii)and (iv) is optionally substituted with 1 to 8 groups selected from thegroup consisting of —OH, —OR, —SH, —SR, —SO₃H, —SO₃R, —SO₂NRR′, —COOH,—COOR, —CONRR′, —NR—C(O)—NRR′, —NRR′ and —N⁺RR′R″, with R, R′ and R″=Hor C1-C6 alkyl; and the substituents of formula (a) to (h) below:

and/or each of (ii), (iii) and (iv) optionally comprises 1 to 8 groups,alone or as a mixture, selected from the group consisting of —S—, S(O),SO₂, —NH— (or =NH), —N=(trivalent), —O—, —C(O)—, —C(═NH)—,—N⁺(CH₃)₂-An⁻, wherein An⁻ is an anion; and the compound of formula(II):


2. The composition according to claim 1, in which R1 represents H and R2represents H, CH₃, C₇H₁₅, C₁₃H₂₇ or aryl.
 3. The composition accordingto claim 1, in which the compound of formula (I) is selected from thegroup consisting of the following compounds:


4. The composition according to claim 1, in which the compound offormula (I), alone or as a mixture, is present in an amount between0.001% and 30% by weight, relative to the total weight of thecomposition.
 5. The composition according to claim 1, in which thecompound of formula (II) is present in an amount between 0.001% and 30%by weight relative to the total weight of the composition.
 6. Thecomposition according to claim 1, in which the cosmetically acceptablemedium comprises at least one ingredient chosen from propellants; water,carbon-based oils; silicone oils; C8-C40 alcohols, C8-C40 esters, C8-C40acids; C1-C7 alcohols, ketones, organic solvents, nonionic surfactants,cationic surfactants, anionic surfactants, amphoteric surfactants,zwitterionic surfactants; sunscreens; moisturizers; antidandruff agents;antioxidants; reducing agents; oxidation bases, couplers, oxidizingagents, direct dyes; hair straightening agents, pearlescent agents andopacifying agents; plasticizers or coalescence agents; hydroxy acids;pigments; fillers; silicones; polyols; waxes; thickeners, emulsifiers;polymers; preservatives, pH agents.
 7. The composition according toclaim 1, which is in the form of a product for caring for, cleansingand/or making up bodily or facial skin, the lips, the eyebrows, theeyelashes, the nails and the hair, an antisun or self-tanning product, abody hygiene product, or a haircare product.
 8. The compositionaccording to claim 1, which is in the form of a haircare composition,for the care and cosmetic treatment.
 9. A method for the cosmetictreatment of keratin materials, comprising the application to saidmaterials of a cosmetic composition as defined in claim
 1. 10. Themethod according to claim 9, for conditioning and/or caring for thehair, in particular for imparting body and/or liveliness thereto, orimproving the disentangling, smoothing, combability, repair andmanageability of the head of hair.
 11. A kit comprising a firstcomposition for dyeing, bleaching, permanent waving, straightening orsmoothing the hair and a cosmetic composition as defined in claim 1,wherein said first composition and said cosmetic composition areseparate from each other in said kit.
 12. The composition according toclaim 2, in which the compound of formula (I) is present in an amountbetween 0.001% and 30% by weight, relative to the total weight of thecomposition.
 13. The composition according to claim 3, in which thecompound of formula (I) is present in an amount between 0.001% and 30%by weight, relative to the total weight of the composition.
 14. Thecomposition according to claim 2, in which the cosmetically acceptablemedium comprises at least one ingredient chosen from propellants; water,carbon-based oils; silicone oils; C8-C40 alcohols, C8-C40 esters, C8-C40acids; C1-C7 alcohols, ketones, organic solvents, nonionic surfactants,cationic surfactants, anionic surfactants, amphoteric surfactants,zwitterionic surfactants; sunscreens; moisturizers; antidandruff agents;antioxidants; reducing agents; oxidation bases, couplers, oxidizingagents, direct dyes; hair straightening agents, pearlescent agents andopacifying agents; plasticizers or coalescence agents; hydroxy acids;pigments; fillers; silicones; polyols; waxes; thickeners, emulsifiers;polymers; preservatives, pH agents.
 15. The composition according toclaim 1, wherein the compound of formula (I) has the following formula:


16. A method for the cosmetic treatment of keratin materials, whichcomprises apply a cosmetic composition as defined in claim 2 to saidmaterials.
 17. The composition according to claim 1, wherein thecompound of formula (I) has a molecular weight of 1200 glmol or less.18. A cosmetic composition comprising, in a physiologically acceptablemedium, a compound having the following formula:

and at least one additional compound of formula (II):

in which: n=1 or 2, and Z″ represents a divalent or trivalent (dependingon the value of n), linear or branched C1-C32 alkyl or C2-C32 alkenylradical; optionally substituted with 1 to 10 radicals selected from thegroup consisting of —OH, —SO₃H, —COOH, —COOR and —N+RR′R″, with R, R′and R″=C1-C12 alkyl, and/or optionally interrupted by 1 to 10 groupsselected from the group consisting of (i) the divalent groups: —S—, —NH—(or ═NH), —O—, —C(O)—, or of formula:

with Ra=H or halogen, or C1-C6 alkyl, or single bond, and R′ and R″,which may be identical or different, representing a hydrogen atom or aC1-C6 alkyl radical; and (ii) the trivalent groups of formula:

R′ representing a hydrogen atom or a C1-C6 alkyl radical.
 19. Thecomposition according to claim 18 wherein Z″ of the compound of formula(II) is optionally substituted with 1 to 10 radicals selected from thegroup consisting of —OH, —SO₃H, —COOH, —COOR and —N+RR′R″, with R, R′and R″=C1-C12 alkyl, and/or optionally interrupted by 1 to 10 groupsselected from the group consisting of (i) the divalent groups: —S—, —NH—(or =NH), —O—, or of formula:


20. The composition according to claim 18 wherein Z″ of the compound offormula (II) is optionally interrupted by 1 to 10 groups selected fromthe group consisting of (i) the divalent groups: —NH— (or =NH), and —O—.21. The composition according to claim 18, in which the compound offormula (I), alone or as a mixture, is present in an amount between0.001% and 30% by weight, relative to the total weight of thecomposition.
 22. The composition according to claim 18, in which thecompound of formula (II), alone or as a mixture, is present in an amountbetween 0.001% and 30% by weight relative to the total weight of thecomposition.
 23. The composition according to claim 18, in which thecosmetically acceptable medium comprises at least one ingredient chosenfrom propellants; water, carbon-based oils; silicone oils; C8-C40alcohols, C8-C40 esters, C8-C40 acids; C1-C7 alcohols, ketones, organicsolvents, nonionic surfactants, cationic surfactants, anionicsurfactants, amphoteric surfactants, zwitterionic surfactants;sunscreens; moisturizers; antidandruff agents; antioxidants; reducingagents; oxidation bases, couplers, oxidizing agents, direct dyes; hairstraightening agents, pearlescent agents and opacifying agents;plasticizers or coalescence agents; hydroxy acids; pigments; fillers;silicones; polyols; waxes; thickeners, emulsifiers; polymers;preservatives, pH agents.
 24. The composition according to claim 18,which is in the form of a product for caring for, cleansing and/ormaking up bodily or facial skin, the lips, the eyebrows, the eyelashes,the nails and the hair, an antisun or self-tanning product, a bodyhygiene product, or a haircare product.
 25. The composition according toclaim 18, which is in the form of a haircare composition, for the careand cosmetic treatment.
 26. A method for the cosmetic treatment ofkeratin materials, comprising the application to said materials of acosmetic composition as defined in claim
 18. 27. The method according toclaim 26, for conditioning and/or caring for the hair, in particular forimparting body and/or liveliness thereto, or improving thedisentangling, smoothing, combability, repair and manageability of thehead of hair.
 28. A kit comprising a first composition for dyeing,bleaching, permanent waving, straightening or smoothing the hair and acosmetic composition as defined in claim 18, wherein said firstcomposition and said cosmetic composition are separate from each otherin said kit.